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Initial, the entire heterogeneity associated with the watched BACs, that is vary from inside the symmetry belonging to the repetitive sequences and also to gene DNA posts, supplies multiple signal hybridization intensities. Minute, like for example gene phrase microarrays, has to be your existence belonging to the “contaminating” nontumoral encompassing cells when you look at the experience. This sort of regular cell got a couple DNA replicas genome wide , also to having said that it is possible to gene expression profiling, the reports isn’t going to supplies some kind of physical review to the browse. So, array–CGH desire to narrow their program you’re able to cases along with fifty% belonging to the tumoral cells, by way of the lower specifications you will income a typical genomic outline comparable to the standard cells . 3rd, will be your production variability among the many more arrays circulated at each and every clinical, for example very few commercially available BAC microarrays.

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